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· CMR1- Canine multifocal retinopathy 1 (CMR1) is an inherited eye disease caused by a mutation (c. 73C>T) in the Bestrophin 1 gene that results in a shortened, dysfunctional protein. Affected dogs typically present with multiple, discrete circular areas of retinal detachment between 11 and 16 weeks of age.
· DM- Degenerative Myelopathy is an inherited neurologic disorder caused by a Mutation of the SOD1 gene known to be carried by French bulldogs. This mutation is found in many breeds of dog, though it is not clear for French bulldogs whether all dogs carrying two copies of the mutation will develop the disease.
· HUU- Hyperuricosuria (HUU) means elevated levels of uric acid in the urine. ... A mutation in exon 5 of the gene Solute carrier family 2, member 9 (SLC2A9) has been found to be associated with hyperuricosuria in dogs. HUU can occur in any breed but is most commonly found in the Dalmatian, Bulldog, and Black Russian Terrier
· JHC- Juvenile hereditary cataract (JHC) affects both eyes symmetrically and has early onset, with cataract formation starting before 1 year of age and progressing to maturity and blindness by 2-3 years of age.
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